Search results for "model [interaction]"
showing 10 items of 1495 documents
Simulated annealing with restrained molecular dynamics using CONGEN: Energy refinement of the NMR solution structures of epidermal and type-αtransfor…
1996
The new functionality of the program CONGEN (Bruccoleri RE, Karplus M, 1987, Biopolymers 26:137-168; Bassolino-Klimas D et al., 1996, Protein Sci 5:593-603) has been applied for energy refinement of two previously determined solution NMR structures, murine epidermal growth factor (mEGF) and human type-alpha transforming growth factor (hTGF alpha). A summary of considerations used in converting experimental NMR data into distance constraints for CONGEN is presented. A general protocol for simulated annealing with restrained molecular dynamics is applied to generate NMR solution structures using CONGEN together with real experimental NMR data. A total of 730 NMR-derived constraints for mEGF a…
Does model consistency in business model innovation matter? A contingency-based approach
2017
Successful business model innovation requires managers to come up not only with new, but also with viable business models. To this end, it has been argued that business model consistency plays a vital role, as the internal fit of business model elements can generate reinforcing effects, thereby influencing performance and competitive advantage. Little research has been conducted to measure consistency and confirm these effects, especially within business model innovation. We tackle this issue by developing and testing a measurement of business model consistency, and investigate its relationship with business model innovation and its performance. We find evidence supporting the positive effe…
Stochastic dynamics of nonlinear systems driven by non-normal delta-correlated processes
1993
In this paper, nonlinear systems subjected to external and parametric non-normal delta-correlated stochastic excitations are treated. A new interpretation of the stochastic differential calculus allows first a full explanation of the presence of the Wong-Zakai or Stratonovich correction terms in the Itoˆ’s differential rule. Then this rule is extended to take into account the non-normality of the input. The validity of this formulation is confirmed by experimental results obtained by Monte Carlo simulations.
Stochastic response of a fractional vibroimpact system
2017
Abstract The paper proposes a method to investigate the stochastic dynamics of a vibroimpact single-degree-of-freedom fractional system under a Gaussian white noise input. It is assumed that the system has a hard type impact against a one-sided motionless barrier, which is located at the system’s equilibrium position; furthermore, the system under study is endowed with an element modeled with fractional derivative. The proposed method is based on stochastic averaging technique and overcome the particular difficulty due to the presence of fractional derivative of an absolute value function; particularly an analytical expression for the system’s mean squared response amplitude is presented an…
Simulation of extreme heat events over the Valencia coastal region: Sensitivity to initial conditions and boundary layer parameterizations
2019
The Valencia coastal region (Western Mediterranean) is especially sensitive to extreme heat events, where they are really common. However, due to its geophysical characteristics and climatic conditions, the incidence of high and extreme temperatures may still be modulated over this area by means of sea breeze circulations, defining a Sea Breeze Convergence Zone (SBCZ) due to the meet and interaction of these mesoscale conditions and Western synoptic-scale wind regimes. A proper definition of this convergence zone is of significant importance over the study area for the simulation and forecast of intense-heat meteorological events. This study analyses a week period in August 2010 over this a…
DNA barcoding for species assignment: the case of Mediterranean marine fishes
2014
Background: DNA barcoding enhances the prospects for species-level identifications globally using a standardized and authenticated DNA-based approach. Reference libraries comprising validated DNA barcodes (COI) constitute robust datasets for testing query sequences, providing considerable utility to identify marine fish and other organisms. Here we test the feasibility of using DNA barcoding to assign species to tissue samples from fish collected in the central Mediterranean Sea, a major contributor to the European marine ichthyofaunal diversity. Methodology/Principal Findings: A dataset of 1278 DNA barcodes, representing 218 marine fish species, was used to test the utility of DNA barcodes…
Computational Analysis Workshop: Comparing Four Approaches to Melodic Analysis
2009
We compare four computational approaches of melodic analysis according to diverse approach aspects: input type (monophonic or polyphonic), pattern identification type (strict or similar), analysis segmentation, aim of approach, motivic pattern representation, and type of result representations. The considered four computational approaches are the following: a similarity neighbourhood approach by Adiloglu (Adiloglu and Obermayer 2006a, b), a multiple viewpoint representation and discovery approach by Anagnostopoulou (Anagnostopoulou, Share and Conklin 2006), a topological approach by Buteau (2005), and an approach based on multidimensional closed pattern mining by Lartillot (Lartillot and To…
A comprehensive integrated membrane bioreactor model for greenhouse gas emissions
2018
Abstract A comprehensive integrated membrane bioreactor (MBR) model for wastewater treatment is here proposed. The model quantifies the main biological and physical processes. The model describes the biological removal of organic matter, nitrogen and phosphorus including greenhouse gases (carbon dioxide, CO 2 and nitrous oxide, N 2 O). The model takes into account the following main innovative aspects jointly: i. Two-step nitrification process; ii. N 2 O formation due to ammonia-oxidizing bacteria as a product of the hydroxylamine oxidation (NH 2 OH) and of the nitrite (NO 2 − ) reduction; iii. Soluble microbial product (SMP) formation/degradation due to microbial growth and endogenous resp…
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A co…
2020
Abstract Background Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation. Methods Modulation of glycolytic gene expression was evaluated by PCR arrays in tumour cells and primary cultures growing under hypoxia, in spheroids and after PCFT silencing. Inhibitors of lactate dehydrogenase (LDH-A) were tested in vitro and in vivo. LDH-A expression was determined in tissue microarrays of radically resected malignant pleural mesothelioma (MPM, N = 33) and diffuse peritoneal mesothelioma (DMPM, N = 56) patients. Results Overexpression of hypoxia…
Convergent adaptation of Saccharomyces uvarum to sulfite, an antimicrobial preservative widely used in human-driven fermentations
2021
Different species can find convergent solutions to adapt their genome to the same evolutionary constraints, although functional convergence promoted by chromosomal rearrangements in different species has not previously been found. In this work, we discovered that two domesticated yeast species, Saccharomyces cerevisiae, and Saccharomyces uvarum, acquired chromosomal rearrangements to convergently adapt to the presence of sulfite in fermentation environments. We found two new heterologous chromosomal translocations in fermentative strains of S. uvarum at the SSU1 locus, involved in sulfite resistance, an antimicrobial additive widely used in food production. These are convergent events that …